| 学习和科研经历 2001.9~2005.6 南京大学化学化工学院毕业，获学士学位 2005.9~2008.6 南京大学化学化工学院毕业，获硕士学位 2008.9~2012.6 英国华威大学化学系毕业，获博士学位 2012.12~2013.5 中国科学院化学研究所，高级访问学者 2013.6~2015.3 中国科学院化学研究所，助理研究员 2015.4~ 中国科学院化学研究所，副研究员 代表文章 L. Qi, Q. Luo, Y. Zhang, F. Jia, Y. Zhao*, F. Wang*, Advances in Toxicological Research of the Anticancer Drug Cisplatin, Chem. Res. Toxicol. 2019, 32(8), 1469-1486. Y. Lin, J. Wang, W. Zheng, Q. Luo, K. Wu, J. Du,* Y. Zhao *, F. Wang*, Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue, Metallomics, 2019, 11, 546-555. Yumiao Han, Wei Guo, Wei Zheng, Qun Luo, Kui Wu, Yao Zhao*, Fuyi Wang, Mass spectrometric quantification of the binding ratio of metal-based anticancer complexes with protein thiols, Rapid Commun Mass Spectrom. 2019; 33, 951–958. J. Du, Y. Y. Wei, Y. Zhao*, F. M. Xu, Y. Y. Wang, W. Zheng, Q. Luo, M. Wang and F. Y. Wang,* A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein, Inorg. Chem. 2018, 57, 5575-5584. C. F. Shao, Y. Zhao* K. Wu, F. F. Jia, Q. Luo, Z. Liu*and F. Y. Wang, Correlated Secondary Ion Mass Spectrometry-Laser Scanning Confocal Microscopy Imaging for Single Cell-Principles and Applications, Chinese J. Anal. Chem. 2018, 46, 1005-1016. W. Zheng, Y. Zhao,* Q. Luo, Y. Zhang, K. Wu and F. Y. Wang,* Multi-Targeted Anticancer Agents (invited review), Current Topics in Medicinal Chemistry, 2017, 17, 3084-3098 J. Du, Y. Kang, Y. Zhao,* W. Zheng, Y. Zhang, Yu Lin, Z. Y. Wang, Y. Y. Wang, Q. Luo, Kui Wu, and F. Y. Wang,* Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines, Inorg. Chem., 2016, 55, 4595-4605. W. Zheng, Y. Zhao*, Q. Luo, Y. Zhang, K. Wu, F. Y. Wang*, Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes, Sci China Chem, 2016, 59(10), 1240-1249. J. Du, E. L. Zhang, Y. Zhao,* W. Zheng, Y. Zhang, Y. Lin, Z. Y. Wang, Q. Luo, K. Wu, F. Y. Wang*, Dscovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells, Metallomics, 2015, 7, 1573-1583. S.Y. Liu, K. Wu,* W. Zheng, Y. Zhao, Q. Luo, S. X. Xiong, F. Y. Wang,* Identification and Discrimination of Binding Sites of an Organoruthenium Anticancer Complex to Single-Stranded Oligonucleotides by Mass Spectrometry, Anlayst, 2014, 10.1039/c4an00807c G. J. Zhai, X. Y. Wu, Q. Luo, K. Wu, Y. Zhao, Y. L. Min, J. A. Liu, X. S. Xiong, Y. Q. Feng, L. P. Yang,* F. Y. Wang,* Absolute Quantification of Serum Phosphopeptides by Mass Spectrometry Coupled to Titania Coated Magnetic Mesoporous Silica Microsphere Enrichment, Talanta, 2014, 125, 411–417 Z. F. Du, Q. Luo, L. P. Yang, T. Bing, X. C. Li, W. Guo, K. Wu, Y. Zhao, S. X. Xiong, D. H. Shangguan, F. Y. Wang,* Mass Spectrometric Proteomics Reveals that Nuclear Protein Posi-tive Cofactor PC4 Selectively Binds to Crosslinked DNA by a Trans-platinum Anticancer Complex, J. Am. Chem. Soc. 2014, 136, 2948-2951 W. Zheng, Q. Luo, Y. Lin, Y. Zhao, X. Wang, Z. Du, X. Hao, Y. Yu, S. Lu, L. Ji, X. Li, L. Yang, F.-Y. Wang*, Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis, Chem. Commun. 2013, 49, 10224-10226. W. Guo, W. Zheng, Q. Luo, X. Li, Y. Zhao, S. Xiong, F.-Y. Wang,* Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells, Inorg. Chem. 2013, 52, 5328-5338. Y. Zhao, N. J. Farrer, H. Li, J. S. Butler, R. J. McQuitty, A. Habtemariam, F.-Y. Wang*, P. J. Sadler*, De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex, Angew. Chem. Int. Ed. 2013, 52, 13633-13637. Zhao, Y; Woods, J. A. Farrer, N. J.; Robinson, K. S.; Pracharova, J.; Kasparkova, J.; Novakova, O.; Li, H.; Salassa, L.; Pizarro, A. M.; Clarkson, G. J.; Song, L,; Brabec, V.; Sadler, P. J.*; Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts, Chem. Eur. J, 2013, 19, 9578-959 Zhao, Y.; Roberts, G. M.; Greenough, S. E.; Farrer, N. J.; Paterson, M. J.; Powell, W. H.; Stavros, V. G.; Sadler, P. J.*, Two-photon-activated ligand exchange in platinum(II) complexes. Angew. Chem. Int. Ed. 2012, 51 (45), 11263-11266. Tai, H.-C.#; Zhao, Y.#; (#, equal contribution) Farrer, N. J.; Anastasi, A. E.; Clarkson, G.; Sadler, P. J.*; Deeth, R. J.*, A computational approach to tuning the photochemistry of platinum(IV) anticancer agents, Chem. Eur. J, 2012, 18 (34), 10630-10642. Li, H.; Wells, S. A.; Jimenez-Roldan, J. E.; R？mer, R. A.; Zhao, Y.; Sadler, P. J.; O'Connor, P. B.*, Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Sci. 2012, 21 (9), 1269-1279. Li, H.; Lin, T.-Y.; Van Orden, S. L.; Zhao, Y.; Barrow, M. P.; Pizarro, A. M.; Qi, Y.; Sadler, P. J.; O’Connor, P. B.*, Use of Top-Down and Bottom-Up Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Mapping Calmodulin Sites Modified by Platinum Anticancer Drugs. Anal. Chem. 2011, 83 (24), 9507-9515. Li, H.; Zhao, Y.; Phillips, H. I. A.; Qi, Y.; Lin, T.-Y.; Sadler, P. J.; O’Connor, P. B.*, Mass Spectrometry Evidence for Cisplatin As a Protein Cross-Linking Reagent. Anal. Chem. 2011, 83 (13), 5369-5376. Farrer, N. J.; Woods, J. A.; Salassa, L.; Zhao, Y.; Robinson, K. S.; Clarkson, G.; Mackay, F. S.; Sadler, P. J.*, A Potent Trans-Diimine Platinum Anticancer Complex Photoactivated by Visible Light. Angew. Chem. Int. Ed. 2010, 49 (47), 8905-8908. Kan, X.; Geng, Z.; Zhao, Y.; Wang, Z.*; Zhu, J.-J.*, Magnetic molecularly imprinted polymer for aspirin recognition and controlled release. Nanotechnology 2009, 20 (16), 165601. Kan, X. W.; Zhao, Y.; Geng, Z. R.; Zhu, J. J.*; Wang, Z. L.*, Composites of multiwalled carbon nanotubes and molecularly imprinted polymers for dopamine recognition. J. Phys. Chem. C 2008, 112 (13), 4849-4854. |
