Education and Work Experience
l 1983.6: BSc., Central China Normal University
l 1991.6: MSc., Central China Normal University
l 1999.7: Ph.D., Wuhan University
l 1991 – 1997 Lecturer, Analysis Center, Central China Normal University
l 1997 – 1999: Associate professor, Analysis Center, Central China Normal University
l 2000 – 2002: Royal Society (UK) Research Fellow, University of Edinburgh
l 2002 – 2007: Research Associate, University of Edinburgh
l 2007 – now： Hundred Talent Program Professor, Institute of Chemistry, CAS
Professional Qualifications
l Executive Member of the Chinese Society for Mass Spectrometry
l Associate Member of the Chinese Human Proteome Organisation
Selective Publications
l K. Wu, W. Hu, Q. Luo, X. Li, S. Xiong, P. Sadler, F.-Y. Wang*, Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry: ladder-sequencing vs top-down, J. Am. Soc. Mass. Spectrom., 2013, 24, 410-420.
l S. Lü, W. Zheng, L. Ji, Q. Luo, X. Hao, X. Li, F.-Y. Wang*, Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors, Eur. J. Med. Chem. 2013, 61, 84-94.
l L. Ji, J.-H. Wu, Q. Luo, X. Li, W. Zheng, G. Zhai, F.-Y. Wang*, S. Lü, Y.-Q. Feng*, J. Liu, S. Xiong, Quantitative Mass Spectrometry Combined with Separation and Enrichment of Phosphopeptides by Titania Coated Magnetic Mesoporous Silica Microspheres for Screening of Protein Kinase Inhibitors, Anal. Chem. 2012, 84, 2284-2291.
l K. Wu, Q. Luo, W. Hu, X. Li, F.-Y. Wang*, S. Xiong, P. J. Sadler*, Mechanism of Interstrand Migration of Organoruthenium Anticancer Complexes within a DNA Duplex, Metallomics, 2012, 4, 136-148.
l Y. M. Han, Q. Luo, X. Hao, X. C. Li, F. Y. Wang,* W. B. Hu, K. Wu, S. Lü, P. J. Sadler*, reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide - a model for the active-site cysteine of protein tyrosine phosphatase 1B, Dalton Trans. 2011, 40, 11519-11529
l W.B. Hu, Q. Luo, K. Wu, X.C. Li, F.Y. Wang,* Y. Chen, X.Y. Ma, J.P. Wang, J.A. Liu,a S.X. Xiong, P.J.. Sadler*, the anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin, Chem. Commun. 2011, 47, 6006–6008.
l W. B. Hu, J. A. Liu, Q. Luo,* Y. M. Han, K. Wu, S. Lv, S. X. Xiong, F. Y. Wang,* Elucidation of the Binding Sites of Sodium Dodecyl Sulfate to b-Lactoglobulin Using Hydrogen/Deuterium Exchange Mass Spectrometry Combined with Docking Simulation, Rapid Commun. Mass Spectrom. 2011, 25, 1429-1436.
l S. Lv, Q. Luo, X. C. Li, K. Wu, J. A. Liu, S. X. Xiong, Y.Q. Feng, F.Y. Wang*, Inhibitor Screening of Protein Kinases Using MALDI-TOF MS Combined with Separation and Enrichment of Phosphopeptides by TiO2 Nanoparticle Deposited Capillary Column, Analyst, 2010, 135, 2858-2863.
l W. B. Hu, Q. Luo, X. Y. Ma, K. Wu, J. A. Liu, Y. Chen, S. X. Xiong, J. P. Wang, P. J. Sadler, F. Y. Wang,* arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes, Chem. Eru. J. 2009, 15, 6586-6594
l F. Y. Wang,* A. Habtemariam, E. P. L. van der Geer, R. J. Deeth, R. Gould, S. Parsons, P. J. Sadler,* synthesis, characterization and reaction pathway for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex, J. Biol. Inorg. Chem., 2009, 14, 1065-1076
l F.Y. Wang, S. Weidt, J. Xu, C. L. Mackay, P. R. R. Langridge-Smith, P. J. Sadler, identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with 18O-labeling, J. Am. Soc. Mass Spectrom. 2008, 19, 544-549
l F. Y. Wang, A. Habtemariam, E. P. L. van der Geer, R. Fernández, M. Melchart, R. J. Deeth, R. Aird, S. Guichard, F. P. A. Fabbiani, P. Lozano-Casal, I. D. H. Oswald, D. I. Jodrell, S. Parsons, P. J. Sadler, controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity, Proc. Natl. Acad. Sci. USA. 2005, 102, 18269-18274.
l F. Y. Wang, J. Xu, A. Habtemariam, J. Bella, P. J. Sadler, competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: detection of a sulfenato intermediate. J. Am. Chem. Soc. 2005, 127, 17734-17743.
l F. Y Wang, H. M. Chen, S. Parsons, I. D. H. Oswald, J. E. Davidson, P. J. Sadler, kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts. Chem. Eur. J. 2003, 9, 5810-5820.
l F. Y. Wang, H. M. Chen, J. A. Parkinson, P. D. Murdoch, P. J. Sadler, reactions of a ruthenium(II) arene antitumor complex with cysteine and methionine. Inorg. Chem. 2002, 41, 4509-4523.
For more publications by Wang group, please click “Publications”.
Current Research Projects
l 2012.1-2016.12, NSFC National Major Research Project on Scientific Instruments: High resolution and multi-functional chemical imaging system (21127901), 8.7 million CNY
l 2012.1-2016.12, NSFC Key Project：Methodology for investigations on interactions between regulating protein and DNA damaged by drug (21135006), 3 million CNY
l 2011.1-2013.12, NSFC Major International Cooperation Project: Methodology for interactromics of metal-based anticancer agents (21020102039)，2.6 million CNY
l 2010.1-2012.12, NSFC General Project: Investigation of interactions between organometallic ruthenium anticancer complexes and serum proteins (20975103), 0.35 million CNY
