课题组长：汪福意 研究员、博士生导师

出生年月：1964年2月

电话：010-62529069

Email: fuyi.wang@iccas.ac.cn

学习经历

工作经历

学术任职

• 历任中国质谱学会常务理事、生物质谱专业委员会副主任，中国生物化学与分子生物学学会蛋白质组专业委员会委员, 现任北京质谱学会副理事长，《质谱学报》编委。

代表论文

 
Y. Lin, J. Wang, W. Zheng, Q. Luo, K. Wu, J. Du,* Y. Zhao *,  F. Wang*, Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue, Metallomics, 2019, 11, 546-555. 
W. Zeng, Y. Zhang, W. Zheng, Q. Luo, J. Han, J. Liu, Y. Zhao, F. Jia, K. Wu*, and F. Wang*, Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry, Molecules, 2019, 24, 1852.
L. Qi, Q. Luo, Y. Zhang, F. Jia, Y. Zhao*, F. Wang*, Advances in Toxicological Research of the Anticancer Drug Cisplatin, Chem. Res. Toxicol. 2019, 32(8), 1469-1486.

Y. Zhang, W. Zeng, L. Huang, W. Liu, E. Jia, Y. Zhao, F. Wang*, Z. Zhu*, In Situ Liquid Secondary Ion Mass Spectrometry: A Surprisingly Soft Ionization Process for Investigation of Halide Ion Hydration, Anal. Chem. 2019, 91, 7039-7046.

W. Zeng, Z. Du, Q. Luo, Y. Zhao, Y. Wang, K. Wu, F. Jia, Y. Zhang,* F. Wang*, Proteomic Strategy for Identification of Proteins Responding to Cisplatin-Damaged DNA, Anal. Chem. 2019, 91, 6035-6042.

Y. Zhang, J.G. Wang, X. Yu, D. R. Baer, Y. Zhao, L. Mao, F. Wang,* Z. Zhu*, Potential-Dynamic Surface Chemistry Controls the Electrocatalytic Processes of Ethanol Oxidation on Gold Surfaces, ACS Energy Lett. 2019, 4, 215-221.
J. Du, Y. Y. Wei, Y. Zhao*, F. M. Xu, Y. Y. Wang, W. Zheng, Q. Luo, M. Wang and F. Y. Wang,* A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein, Inorg. Chem. 2018, 57, 5575-5584.
Y. Y. Zhang, M. Su, X. F. Yu, Y. F. Zhou, J. G. Wang, R. G. Cao, W. Xu, C. M. Wang, D. R. Baer, O. Borodin, K. Xu, Y. T. Wang, X. L. Wang, Z, J. Xu, F. Y. Wang* and Z. H. Zhu*，Investigation of Ion-Solvent Interactions in Nonaqueous Electrolytes Using in Situ Liquid SIMS, Anal. Chem. 2018, 90, 3341-3348.
Y. Zhang, Q. Luo, W. Zheng,* Z. Y. Wang, Y. Lin, E. L. Zhang, S. Lü, J. F. Xiang, Y. and F. Y. Wang*, Luminescent cyclometallated platinum(II) complexes: highly promising EGFR/DNA probes and dual-targeting anticancer agents, Inorg. Chem. Front. 2018, 5, 413-424.

 Y. Y. Cheng, W. J. Zeng, Y. Cheng, J. S. Zhang, T. Zou, K. Wu* and F. Y. Wang*, Selective binding of an organoruthenium complex to G-rich human telomeric sequence by tandem mass spectrometry, Rapid Commun. Mass Spectrom. 2018, 32, 2152-2158.

Z. Y. Wang, Y. Y. Zhang, B. W. Liu, K. Wu, S. Thevuthasan, D. R. Baer, Z. H. Zhu,* X. Y. Yu* and F. Y. Wang*, In situ Mass Spectrometric Monitoring of the Dynamic Electrochemical Process at the Electrode-Electrolyte Interface: a SIMS Approach, Anal. Chem. 2017, 89, 960-965.

S. Y. Liu, W. Zheng, K. Wu,* Y. Lin, F. F. Jia, Y. Zhang, Z. Y. Wang, Q. Luo, Y. Zhao, F. Y. Wang* Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex, Chem. Commum. 2017, 53, 4136-4139.

Y. L. Jin, Y. F. Xie, K. Wu, Y. Y. Huang,* F. Y. Wang,* R. Zhao,* Probing the Dynamic Interaction between Damaged DNA and a Cellular Responsive Protein Using a Piezoelectric Mass Biosensor, ACS Appl. Mater. Interfaces 2017, 9, 8490-8497.

Y. Y. Wang, Z. F. Du,* W.  Zheng, K. Wu, D. C. Xu, Q. Luo, Y.  Zhao, J. J. Han, Y. Z. Liu, F. Y. Wang,* Deciphering of Interactions between Platinated DNA and HMGB1 by Hydrogen/Deuterium Exchange Mass Spectrometry, Dalton Trans. 2017, 46, 6133-6484.

K. Wu,  F. F. Jia, W. Zheng, Q. Luo, Y. Zhao, F. Y. Wang,* Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging, J. Biol. Inorg. Chem. 2017, 22, 653-661.

W. Zheng, Y. Zhao*, Q. Luo, Y.  Zhang, K.  Wu, F. Y. Wang*, Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes, Sci China Chem, 2016, 59(10), 1240-1249.

J. Du, Y. Kang, Y. Zhao,* W. Zheng, Y. Zhang, Yu Lin, Z. Y. Wang, Y. Y. Wang, Q. Luo, Kui Wu, and F. Y. Wang,* Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines, Inorg. Chem., 2016, 55, 4595-4605.

L. J. Li, W. Guo, K. Wu,* X. L. Wu, L. H. Zhao, Y. Zhao, Q. Luo, Y. Y. Wang, Y. Z. Liu, Q. W. Zhang, F. Y. Wang,* A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry, J. Inorg. Biochem., 2016, 161, 99-106.

Z. Y. Wang, J. Liu, Y. F.  Zhou J. J. Neeway, D. K. Schreiber, J. V. Crum, J. V. Ryan, X. L. Wang, F. Y. Wang,* Z. H. Zhu,* Nanoscale imaging of Li and B in nuclear waste glass, a comparison of ToF-SIMS, NanoSIMS, and APT, Surf. Interface Anal. 2016, 48, 1392-1401.

J. Du, E. L. Zhang, Y. Zhao,* W. Zheng, Y. Zhang, Y. Lin, Z. Y. Wang, Q. Luo, K. Wu, F. Y. Wang*, Dscovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells, Metallomics, 2015, 7, 1573-1583.

Y. Zhang, W. Zheng,* Q. Luo, Y. Zhao, E. L. Zhang, S. Y. Liu, F. Y.  Wang,* Dual-targeting organometallic ruthenium(II) anticancer complexes bearing EGFR-inhibiting 4-anilinoquinazoline ligands, Dalton Trans. 2015, 44, 13100–131.

Z. Y. Wang, B. W. Liu, E. W. Zhao, K. Jin, Y. G. Du, J. J. Neeway, J. V. Ryan, D. H. Hu, K. H. L. Zhang, M. Hong, S. Le Guernic, S. Thevuthasan, F. Y. Wang,* Z. H.  Zhu*, Argon Cluster Sputtering Source for ToF-SIMS Depth Profiling of Insulating Materials: High Sputter Rate and Accurate Interfacial Information, , J. Am. Soc. Mass Spectrom., 2015, 26, 1283-1290

S. Y. Liu, K. Wu,* W. Zheng, Y. Zhao, Q. Luo, S. X. Xiong, F. Y. Wang,* Identification and Discrimination of Binding Sites of an Organoruthenium Anticancer Complex to Single-Stranded Oligonucleotides by Mass Spectrometry, Anlayst, 2014, 10.1039/c4an00807c.

G. J. Zhai, X. Y. Wu, Q. Luo, K. Wu, Y. Zhao, Y. L. Min, J. A. Liu, X. S. Xiong, Y. Q. Feng, L. P. Yang,* F. Y. Wang,* Absolute Quantification of Serum Phosphopeptides by Mass Spectrometry Coupled to Titania Coated Magnetic Mesoporous Silica Microsphere Enrichment, Talanta, 2014, 125, 411–417.

Z. Du, Q. Luo, L. Yang, T. Bing, X. Li, W. Guo, K. Wu, Y. Zhao, S. Xiong, D. Shangguan, F.-Y. Wang*, Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex, J. Am. Chem. Soc. 2014, 136, 2948-2951.

Y. Zhao, N. J. Farrer, H. Li, J. S. Butler, R. J. McQuitty, A. Habtemariam, F.-Y. Wang*, P. J. Sadler*, De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex, Angew. Chem. Int. Ed. 2013, 52, 13633-13637.

  
 

浏览汪福意课题组更多发表著作请点击“论文著作”。

承担的科研项目

1. 2020.1 – 2024.12， 国家自然科学基金委国家重大科研仪器研制项目：高质量分辨原位液相二次离子质谱系统（21927804），项目负责人，总经费800万元

2. 2016.1 – 2019.12， 国家自然科学基金委面上项目：基于化学遗传学的金属抗肿瘤药物分子作用机理研究新方法（21575145），项目负责人，总经费78万

3. 2013.1 – 2017.12，国家重点基础研究发展计划（973计划）项目：基于利水功效的中药药性理论研究，子课题（2013CB531805）负责人，总经费402万元（项目总经费2300万元）（已结题）

2012.1 – 2016.12，国家自然科学基金委国家重大科研仪器研制项目：高分辨多功能化学成像系统，骨干成员，超分辨光学成像-二次离子质谱成像联用系统研制子课题负责人，子课题经费 900万元 （项目总经费 7000万元） （已结题）

2. 2012.1 – 2016.12，国家自然科学基金重点项目：调控蛋白与药物损伤DNA相互作用研究的分析新方法（21135006），项目负责人，总经费300万元 （已结题）

3.  2011.1 – 2013.12，国家自然科学基金委重大国际合作项目：金属抗肿瘤药物相互作用组学的方法学研究（21020102039），项目负责人，总经费260万元 （已结题）

4. 2010.1 – 2012.12, 国家自然科学基金委面上项目：LC-MS研究金属抗肿瘤药物与血清蛋白的相互作用（20975103），项目负责人，总经费 35万元 （已结题）

5. 2008.1 – 2010.12，国家自然科学基金重大研究计划项目：基于信号转导过程的组合分子抗癌药物的设计和作用机理研究（90713020），项目负责人，总经费50万元（已结题）

6. 2007.3 – 2007.12，国家自然科学基金科学部主任基金项目：液质联用和多维核磁波谱研究组合分子抗癌药物与生物靶分子的相互作用（20745002），项目负责人，总经费8万元（已结题）

7. 2007.9 – 2011.8，科技部973重大基础研究项目（课题）：单分子荧光成像和单分子力谱用于重要信号转导蛋白的研究（2007CB935601），子课题经费625万元，主要成员（已结题）